TitleStructure homology and interaction redundancy for discovering virus-host protein interactions
Publication TypeJournal Article
Year of Publication2013
Authorsde Chassey B\^ıt, Meyniel-Schicklin L, Aublin-Gex A, Navratil V, Chantier T, André P, Lotteau V
JournalEMBO Rep
Volume14
Pagination938-44
Date PublishedOct
Abstract

Virus-host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction of such interactomes is, however, technically challenging and time consuming. Here we describe an original method for the prediction of high-confidence interactions between viral and human proteins through a combination of structure and high-quality interactome data. Validation was performed for the NS1 protein of the influenza virus, which led to the identification of new host factors that control viral replication.

DOI10.1038/embor.2013.130
PubMed ID24008843
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