Title[Genetic aspects of renal tumors in adults].
Publication TypeJournal Article
Year of Publication1992
AuthorsFournet JC, Béroud C, Austruy E, Léonard C
JournalArchives d'anatomie et de cytologie pathologiques
Volume40
Pagination301–306
Abstract

The aetiopathogenesis of adult renal tumors is poorly understood. The specific chromosomal changes detected by the study of tumor karyotypes suggest a cascade of oncogene activation and tumor suppressor gene inactivation in the course of renal carcinogenesis. These cytogenetic studies have isolated two entities: non-papillary carcinomas (clear cell and/or eosinophil carcinomas) and tubulopapillary tumors (cortical adenoma, basophil papillary carcinoma). Specific changes of the short arm of chromosome 3 are observed in 70 to 85% of cases of clear cell carcinomas, while trisomy 17 is detected in 70% of cases of tubulopapillary tumors. Cytogenetics is also able to distinguish low and high grade malignant tubulopapillary carcinomas. Limited data are available at the present time concerning oncocytomas.

URLhttp://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=1304117&retmode=ref&cmd=prlinks
PubMed ID1304117
cea
cnrs
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